We demonstrate a SNP (Single Nucleotide Polymorphism) nomenclature centralization application to resolve the heterogeneous representations of SNPs. As NGS techniques become popular, overwhelming data introduces chaos for efficient management of genomic variants, especially SNPs. There has been an explosion of data available for public use. SNP databases such as dbSNP, GWAS (formerly HGVbaseG2P), HapMap and JSNP have collected millions of records. But the same SNP may be assigned different identities in these databases.
UASIS (Universal Automatic SNP Identification System) is a web application for SNP nomenclature standardization and translation. Three utilities are available. They are UASIS Aligner, Universal SNP Name Generator and SNP Name Mapper. UASIS maps SNPs from different databases, including dbSNP, GWAS, HapMap and JSNP etc., into an uniform view efficiently using a proposed universal nomenclature and state-of-art alignment algorithms.